Laduviglusib (trihydrochloride)

MedChem Express

Laduviglusib (trihydrochloride) [1782235-14-6]

10

1782235-14-6

Research Use Only

99.35

C22H21Cl5N8

574.72

Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy [1] [2] [3] .

N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl

2°C to 8°C

12352200