Laforin antibody, Internal

GeneTex

Laforin antibody, Internal

9

WB: 0.1-0.3microg/ml. IHC-P: 2.5-3.8microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

EPM2A

EPM2A glucan phosphatase, laforin

EPM2, MELF, MELF2, laforin, EPM2A, laforin glucan phosphatase, LAFPTPase, epilepsy, progressive myoclonus type 2, Lafora disease (laforin), epilepsy, progressive myoclonus type 2A, Lafora disease (laforin), glucan phosphatase, glycogen phosphatase, lafora PTPase

Goat

IgG

Laforin

This gene encodes a dual-specificity phosphatase and may be involved in the regulation of glycogen metabolism. The protein acts on complex carbohydrates to prevent glycogen hyperphosphorylation, thus avoiding the formation of insoluble aggregates. Loss-of-function mutations in this gene have been associated with Lafora disease, a rare, adult-onset recessive neurodegenerative disease, which results in myoclonus epilepsy and usually results in death several years after the onset of symptoms. The disease is characterized by the accumulation of insoluble particles called Lafora bodies, which are derived from glycogen. [provided by RefSeq, Jan 2018]

-20°C or -80°C,2°C to 8°C

12352203