ProductsBack/LAG3 antibody [17B4]

LAG3 antibody [17B4]

Name: LAG3 antibody [17B4]
SKU: GTX33931_G10
Availability: BackOrder

GTX33931

ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking

Product group Antibodies

ReactivityHuman

TargetLAG3

Overview

Supplier
GeneTex
Product Name
LAG3 antibody [17B4]
Delivery Days Customer
9
Application Supplier Note
IHC-Fr: . *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
17B4
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID3902
Target name
LAG3
Target description
lymphocyte activating 3
Target synonyms
CD223, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3
Host
Mouse
Isotype
IgG1
Protein IDP18627
Protein Name
Lymphocyte activation gene 3 protein
Scientific Description
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Reactivity
Human
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Casati C, Camisaschi C, Novellino L, et al. Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation. J Immunol. 2008,180(6):3782-8.
Read this paper
Triebel F, Hacene K, Pichon MF. A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. Cancer Lett. 2006,235(1):147-53.
Read this paper
Maçon-Lemaître L, Triebel F. The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells. Immunology. 2005,115(2):170-8.
Read this paper
Di Carlo E, Cappello P, Sorrentino C, et al. Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway. J Pathol. 2005,205(1):82-91.
Read this paper
Demeure CE, Wolfers J, Martin-Garcia N, et al. T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts. Eur J Cancer. 2001,37(13):1709-18.
Read this paper
Hannier S, Tournier M, Bismuth G, et al. CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. J Immunol. 1998,161(8):4058-65.
Read this paper
Huard B, Mastrangeli R, Prigent P, et al. Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. Proc Natl Acad Sci U S A. 1997,94(11):5744-9.
Read this paper
Huard B, Gaulard P, Faure F, et al. Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand. Immunogenetics. 1994,39(3):213-7.
Read this paper
Baixeras E, Huard B, Miossec C, et al. Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. J Exp Med. 1992,176(2):327-37.
Read this paper

Datasheet

Download Datasheet

FAQ

Go to our frequently asked questions

LAG3 antibody [17B4]

Large volume orders?

Overview

References

Datasheet

FAQ

Related products