Lamin A + C antibody [GT1137]

GeneTex

Lamin A + C antibody [GT1137] - Recombinant antibody, KO/KD, Orthogonal Validated

9

WB: 1:50000 - 1:200000. ICC/IF: 1:50 - 1:1000. IHC-P: 1:50 - 1:1000. IP: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

GT1137

Unconjugated

LMNA

lamin A/C

CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, MADA, PRO1, lamin, 70 kDa lamin, epididymis secretory sperm binding protein, lamin A/C-like 1, lamin C, mandibuloacral dysplasia type A, prelamin-A/C, progerin, renal carcinoma antigen NY-REN-32

Rabbit

IgG

Prelamin-A/C

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

-20°C or -80°C,2°C to 8°C

12352203