LAP2 alpha antibody, C-term

GeneTex

LAP2 alpha antibody, C-term

9

Reacts with human, rat & mouse LAP2α

Recommended Starting Dilutions:For WB: Use at 1:2500For ICC/IF: Use at 1:250Optimal dilutions should be determined experimentally by the researcher.

Liquid

TMPO

thymopoietin

CMD1T; lamina-associated polypeptide 2; LAP2; LEM domain containing 4; LEMD4; PRO0868; thymopoietin; TP

Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A- type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eu karyotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, and MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. While LAP 2 beta binds to B-type lamins at the nuclear periphery and was suggested to regulate nuclear lamina growth , LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent/salt-resistant nucleoskeletal structure.

-20°C or -80°C,2°C to 8°C

12352203