LARGE (aa421-433) antibody, Internal

GeneTex

LARGE (aa421-433) antibody, Internal

7

WB: 1-3microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.50 mg/ml

Unconjugated

LARGE1

LARGE xylosyl- and glucuronyltransferase 1

LARGE, MDC1D, MDDGA6, MDDGB6, xylosyl- and glucuronyltransferase LARGE1, acetylglucosaminyltransferase-like 1A, acetylglucosaminyltransferase-like protein, glycosyltransferase-like protein LARGE1

Goat

IgG

Xylosyl- and glucuronyltransferase LARGE1

This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]

Human

-20°C or -80°C,2°C to 8°C

12352203