Larixol

MedChem Express

Larixol [1438-66-0]

14

1438-66-0

Research Use Only

C20H34O2

306.48

Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the betagamma subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 microM)-induced superoxide anion production (IC50: 1.98 microM), cathepsin G release (IC50: 2.76 microM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants[1][2].

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12352200