Larixol

Biorbyt

Larixol

10

1438-66-0

Research Use Only

98.00%

C20H34O2

306.48

Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for immune responses. It disrupts the interaction between the betagamma subunit of the Gi protein and downstream effectors linked to the fMLP receptor, thus abrogating fMLP-induced respiratory bursts. Additionally, larixol effectively reduces fMLP (0.1 microM)-triggered superoxide anion generation (IC50: 1.98 microM), cathepsin G secretion (IC50: 2.76 microM), and cellular chemotaxis, mitigating neutrophil hyperactivation and subsequent inflammation or tissue injury. Derivatives of larixol also demonstrate inhibitory activity on TRPC6 functional mutants associated with FSGS [1] [2].

C[C@]12[C@@]([C@@H](O)CC(=C)[C@@H]1CC[C@](C=C)(C)O)(C(C)(C)CCC2)[H]

-20°C

12352200