FACS analysis of MCF-7 cells using GTX80914 LDL Receptor antibody, Internal. Top histogram : negative control Bottom histogram : MCF-7 cells
FACS analysis of MCF-7 cells using GTX80914 LDL Receptor antibody, Internal. Top histogram : negative control Bottom histogram : MCF-7 cells
LDL Receptor antibody, Internal
GTX80914
Overview
- SupplierGeneTex
- Product NameLDL Receptor antibody, Internal
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. FACS: 1:10-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- FormulationLiquid
- Gene ID3949
- Target nameLDLR
- Target descriptionlow density lipoprotein receptor
- Target synonymsFH; FHC; FHCL1; LDL receptor; LDLCQ2; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3
- Protein IDP01130
- Protein NameLow-density lipoprotein receptor
- Scientific DescriptionThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. Romagnuolo R et al., 2015 May 1, J Biol ChemRead more