LE135 [155877-83-1]

MedChem Express

LE135 [155877-83-1]

5

155877-83-1

Research Use Only

99.0

C29H30N2O2

438.56

LE135 is a potent RAR antagonist that binds selectively to RARalpha (Ki of 1.4 microM) and RARbeta (Ki of 220 nM), and has a higher affinity to RARbeta. LE135 is highly selective over RARgamma, RXRalpha, RXRbeta and RXRgamma. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC50s of 2.5 microM and 20 microM, respectively[1][2].

O=C(O)C1=CC=C(C2=NC3=CC4=C(C(C)(C)CCC4(C)C)C=C3N(C)C5=CC=CC=C52)C=C1

-20°C,2°C to 8°C

12352200