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LEF1 antibody

Name: LEF1 antibody
SKU: GTX129186_G10
Availability: BackOrder

GTX129186

ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Rat

TargetLEF1

Overview

Supplier
GeneTex
Product Name
LEF1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID51176
Target name
LEF1
Target description
lymphoid enhancer binding factor 1
Target synonyms
ECTD1, ECTD17, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Host
Rabbit
Isotype
IgG
Protein IDQ9UJU2
Protein Name
Lymphoid enhancer-binding factor 1
Scientific Description
LEF1 is a nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA; MIM 186880) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1; MIM 163905) (Waterman et al., 1991 [PubMed 2010090]; van Genderen et al., 1994 [PubMed 7958926]).[supplied by OMIM]
Reactivity
Human, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Kim HJ, Moon SJ, Hong S, et al. DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300. Nucleic Acids Res. 2022,50(14):7873-7888. doi: 10.1093/nar/gkac585
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Qian F, Wang J, Wang Y, et al. MiR-378a-3p as a putative biomarker for hepatocellular carcinoma diagnosis and prognosis: Computational screening with experimental validation. Clin Transl Med. 2021,11(2):e307. doi: 10.1002/ctm2.307
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Or CR, Huang CW, Chang CC, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling. Int J Mol Sci. 2020,21(5). doi: 10.3390/ijms21051773
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Huang HC, Lin H, Huang MC. Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways. Arch Dermatol Res. 2019,311(5):411-420. doi: 10.1007/s00403-019-01920-1
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Pei YF, Yin XM, Liu XQ. TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway. Biochim Biophys Acta Mol Basis Dis. 2018,1864(1):197-207. doi: 10.1016/j.bbadis.2017.10.019
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