Leptin Receptor antibody [9L34]

GeneTex

Leptin Receptor antibody [9L34]

9

WB: 1:500 - 1:2000. IHC-P: 1:20 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

9L34

500 ug/ml

Unconjugated

LEPR

leptin receptor

CD295; huB219; LEP-R; LEPRD; leptin receptor; OB receptor; OBR; OB-R

Mouse

IgG2

Leptin receptor

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203