Lifitegrast
M5852
CAS Number1025967-78-5
Product group Chemicals
Estimated Purity0.9981
Molecular Weight615.48
Overview
- SupplierAbMole BioScience
- Product NameLifitegrast
- Delivery Days Customer9
- CAS Number1025967-78-5
- Category SupplierChemical
- CertificationResearch Use Only
- Estimated Purity0.9981
- Molecular FormulaC29H24Cl2N2O7S
- Molecular Weight615.48
- Scientific DescriptionLifitegrast is an antagonist of integrin lymphocyte function associated antigen-1 (LFA-1). The IC50 of Jurkat T cells to icAM-1 was 2.98nM. Lifitegrast blocks the interaction between LFA-1 and ICAM-1, thereby reducing T cell activity and cytokine secretion.
- SMILESC[S](=O)(=O)C1=CC=CC(=C1)CC(NC(=O)C2=C(Cl)C=C3CN(CCC3=C2Cl)C(=O)C4=CC=C5C=COC5=C4)C(O)=O
- UNSPSC12352200