LIN7B antibody [1F11]

GeneTex

LIN7B antibody [1F11]

9

WB: 1:2000. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, Western Blot

Research Use Only

Monoclonal

1F11

1 mg/ml

Unconjugated

LIN7B

lin-7 cell polarity scaffold B

LIN-7B, MALS-2, MALS2, VELI2, protein lin-7 homolog B, hLin7B, hVeli2, lin-7 homolog B, crumbs cell polarity complex component, mammalian LIN-7 2, mammalian lin-seven protein 2, veli-2, vertebrate LIN7 homolog 2, vertebrate lin-7 homolog 2

Mouse

IgG2b

Protein lin-7 homolog B

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.

Human

-20°C or -80°C,2°C to 8°C

12352203