Linifanib

MedChem Express

Linifanib [796967-16-3]

10

796967-16-3

99.72

C21H18FN5O

375.40

Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC 50 s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRbeta, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. Linifanib is a specific miR-10b inhibitor that blocks miR-10b biogenesis [1] [2] .

O=C(NC1=CC=C(C2=C3C(N)=NNC3=CC=C2)C=C1)NC4=C(C=CC(C)=C4)F

-20°C,2°C to 8°C

12352200