Livin antibody [1D12]

GeneTex

Livin antibody [1D12] - Overexpression Validated

9

WB: 1:1000. IHC-P: 1:50. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1D12

0.36 mg/ml

Unconjugated

BIRC7

baculoviral IAP repeat containing 7

KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat-containing protein 7, RING finger protein 50, RING-type E3 ubiquitin transferase BIRC7, kidney inhibitor of apoptosis protein, livin inhibitor of apoptosis, melanoma inhibitor of apoptosis protein

Mouse

IgG1

Baculoviral IAP repeat-containing protein 7

Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.

-20°C or -80°C,2°C to 8°C

12352203