Lorlatinib

MedChem Express

Lorlatinib [1454846-35-5]

10

1454846-35-5

99.92

C21H19FN6O2

406.41

Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor with anticancer activity. Lorlatinib has K i s of L1196M , respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC 50 s of 15-43 nM (ALK L1196 ), 14-80 nM (ALK G1269A ), 38-50 nM (ALK 1151Tins ), 77-113 nM (ALK G1202R ), respectively [1] [2] [3] .

CN1C(C#N)=C2C(CN(C)C(C3=C([C@@H](C)OC4=C(N)N=CC2=C4)C=C(F)C=C3)=O)=N1

-20°C,2°C to 8°C

12352200