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ProductsBack/LP-935509 [1454555-29-3]
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LP-935509 [1454555-29-3]

Research Use Only
T15781
TargetMol Chemicals
CAS Number1454555-29-3
DownloadMSDS
Product group Chemicals
Molecular Weight396.44
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    LP-935509 [1454555-29-3]
  • Delivery Days Customer
    9
  • CAS Number
    1454555-29-3
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    LP-935509
  • Molecular Formula
    C20H24N6O3
  • Molecular Weight
    396.44
  • Scientific Description
    LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of cyclin G-associated kinase(GAK, IC50=320 nM). LP-935509 is also a ATP-competitive inhibitor of adapter protein-2 associated kinase 1 (AAK1) (IC50 = 3.3 nM, Ki = 0.9 nM).
  • Shelf life instruction
    3 years
  • SMILES
    COc1ncccc1-c1cnn2ccc(nc12)N1CCN(CC1)C(=O)OC(C)C
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.
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