LT175

MedChem Express

LT175 [862901-87-9]

10

862901-87-9

Research Use Only

99.79

C21H18O3

318.37

LT175, a dual PPARalpha/gamma ligand, is an orally active partial agonist against PPARgamma(hPPARalpha:EC50=0.22 microm; mPPARalpha:EC50=0.26 microm; hPPARgamma:EC50=0.48 microm). LT175 interacts with PPARgamma and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARgamma in a hydrophobic region called diphenyl pocket . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O

-20°C,2°C to 8°C

12352200