LT175 [862901-87-9]

TargetMol Chemicals

LT175 [862901-87-9]

44

862901-87-9

Chemical

Research Use Only

LT175

C21H18O3

318.37

LT175, a dual PPARalpha/gamma ligand, demonstrates potent insulin-sensitizing effects with reduced adipogenic properties. This orally active partial agonist targets PPARgamma with EC50 values of 0.22 microm for hPPARalpha, 0.26 microm for mPPARalpha, and 0.48 microm for hPPARgamma. LT175 specifically interacts with PPARgamma, influencing the recruitment of coregulators, such as the cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1), within a hydrophobic region known as the diphenyl pocket [1].

3 years

OC(=O)[C@H](Cc1ccccc1)Oc1ccc(cc1)-c1ccccc1

-20°C

12352200