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ProductsBack/LV-320 [2449093-46-1]
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CgoaEWY7N6eEEB6TAAAAAGzTuZE268.png

LV-320 [2449093-46-1]

Research Use Only
T11896
TargetMol Chemicals
CAS Number2449093-46-1
DownloadMSDS
Product group Chemicals
Molecular Weight520.11
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    LV-320 [2449093-46-1]
  • Delivery Days Customer
    10
  • CAS Number
    2449093-46-1
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    LV-320
  • Molecular Formula
    C29H26ClNO2S2
  • Molecular Weight
    520.11
  • Scientific Description
    LV-320 is a potent, uncompetitive ATG4B inhibitor with an IC50 of 24.5 microM and a Kd of 16 microM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].
  • Shelf life instruction
    3 years
  • SMILES
    OC(=O)CCSC(SCCc1ccccc1)c1ccc(\C=C\c2ccnc3cc(Cl)ccc23)cc1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Bosc D, et al. A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B. Sci Rep. 2018 Aug 3;8(1):11653. doi: 10.1038/s41598-018-29900-x.
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