LY2811376 [1194044-20-6]

MedChem Express

LY2811376 [1194044-20-6]

10

1194044-20-6

Research Use Only

99.89

C15H14F2N4S

320.36

LY2811376 is the first orally available non-peptidic beta-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Abeta secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.

FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1

-20°C,2°C to 8°C

12352200