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LY2811376 [1194044-20-6]

Research Use Only
HY-10472
MedChem Express
CAS Number1194044-20-6
Product group Chemicals
Estimated Purity98%
Molecular Weight320.36
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    LY2811376 [1194044-20-6]
  • Delivery Days Customer
    10
  • CAS Number
    1194044-20-6
  • Certification
    Research Use Only
  • Estimated Purity
    98%
  • Molecular Formula
    C15H14F2N4S
  • Molecular Weight
    320.36
  • Scientific Description
    LY2811376 is the first orally available non-peptidic beta-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Abeta secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
  • SMILES
    FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200