LY2811376 [1194044-20-6]
HY-10472
CAS Number1194044-20-6
Product group Chemicals
Estimated Purity99.89
Molecular Weight320.36
Overview
- SupplierMedChem Express
- Product NameLY2811376 [1194044-20-6]
- Delivery Days Customer10
- CAS Number1194044-20-6
- CertificationResearch Use Only
- Estimated Purity99.89
- Molecular FormulaC15H14F2N4S
- Molecular Weight320.36
- Scientific DescriptionLY2811376 is the first orally available non-peptidic beta-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Abeta secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
- SMILESFC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352200