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LY294002 [154447-36-6]

Research Use Only
S1105
Selleck Chemicals
CAS Number154447-36-6
Product group Chemicals
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    LY294002 [154447-36-6]
  • Delivery Days Customer
    9
  • CAS Number
    154447-36-6
  • Certification
    Research Use Only
  • Scientific Description
    LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kalfa/delta/bèta with IC50 of 0.5 muM/0.57 muM/0.97 muM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
  • UNSPSC
    12352200