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Chemical Structure
Chemical Structure
Chemical Structure

Lycorine hydrochloride [2188-68-3]

Research Use Only
CDX-L0129
Chemodex
CAS Number2188-68-3
Product group Chemicals
Estimated Purity>98%
Molecular Weight323.77
Price on request
Packing Size
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Overview

  • Supplier
    Chemodex
  • Product Name
    Lycorine hydrochloride [2188-68-3]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    2188-68-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C16H17NO4 . HCl
  • Molecular Weight
    323.77
  • Scientific Description
    Chemical. CAS: 2188-68-3. Formula: C16H17NO4 . HCl. MW: 323.77. Lycorine is an active alkaloid abundant in Amaryllidaceae with a wide range of biological properties, including antifungal, antiparasitic, antiviral, anti-inflammatory and anticancer activity. It is a protein synthesis by preventing amino acid incorporation into proteins, potentially through the inhibition of peptidyltransferases. Lycorine induces cell cycle arrest and cell death in Trichomonas. As anticancer agent on a molecular basis it induces G0/G1 phase cell cycle arrest and apoptosis, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, inhibits the Wnt/beta-catenin pathway, activates ROCK1and inhibits JAK/STAT pathways. Lycorine exhibits antiviral activities against enterovirus, flaviviruses, Zika virus, HIV-1, SARS-CoV, SARS-CoV-2 and hepatitis C virus, most probably by suppressing viral replication. Lycorine has been shown to inhibit NLRP3 inflammasome activation and pyroptosis. - Lycorine is an active alkaloid abundant in Amaryllidaceae with a wide range of biological properties, including antifungal, antiparasitic, antiviral, anti-inflammatory and anticancer activity. It is a protein synthesis by preventing amino acid incorporation into proteins, potentially through the inhibition of peptidyltransferases. Lycorine induces cell cycle arrest and cell death in Trichomonas. As anticancer agent on a molecular basis it induces G0/G1 phase cell cycle arrest and apoptosis, inhibits activity of histone deacetylases (HDACs), upregulates expression of p53 and p21, downregulates expression of cyclin D1 and CDK4, inhibits the Wnt/beta-catenin pathway, activates ROCK1and inhibits JAK/STAT pathways. Lycorine exhibits antiviral activities against enterovirus, flaviviruses, Zika virus, HIV-1, SARS-CoV, SARS-CoV-2 and hepatitis C virus, most probably by suppressing viral replication. Lycorine has been shown to inhibit NLRP3 inflammasome activation and pyroptosis.
  • SMILES
    O[C@H]([C@H]1O)C=C2CCN3CC4=CC5=C(OCO5)C=C4[C@@]1([H])[C@]32[H].Cl
  • Storage Instruction
    2°C to 8°C
  • UN Number
    2811
  • UNSPSC
    12352200