mAChR M2 antibody [B8E5]

GeneTex

mAChR M2 antibody [B8E5]

9

Monoclonal antibody B8E5 acts by functional dimerization of the receptor resulting in stabilization of the constitutive active receptor dimers and paradoxically induces a small decrease in carbachol affinity for the M2 receptor. It recognizes the pentapep

Functional Assay, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

B8E5

100 ug/ml

Unconjugated

CHRM2

cholinergic receptor muscarinic 2

7TM receptor; acetylcholine receptor, muscarinic 2; HM2; muscarinic acetylcholine receptor M2; muscarinic M2 receptor

Mouse

IgG2a

Muscarinic acetylcholine receptor M2

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Guinea Pig, Human, Mouse, Rat

2°C to 8°C

12352203