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MAD1 antibody

GTX105079
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetMAD1L1
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Overview

  • Supplier
    GeneTex
  • Product Name
    MAD1 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8379
  • Target name
    MAD1L1
  • Target description
    mitotic arrest deficient 1 like 1
  • Target synonyms
    MAD1; MAD1 mitotic arrest deficient like 1; MAD1-like protein 1; mitotic arrest deficient 1-like protein 1; mitotic checkpoint MAD1 protein homolog; mitotic spindle assembly checkpoint protein MAD1; mitotic-arrest deficient 1, yeast, homolog-like 1; PIG9; tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y6D9
  • Protein Name
    Mitotic spindle assembly checkpoint protein MAD1
  • Scientific Description
    MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size.
    Read more
  • Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.
    Read more
  • Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation. Chen Q et al., 2021 Sep 21, Cell Rep
    Read more
  • The association of Plk1 with the astrin-kinastrin complex promotes formation and maintenance of a metaphase plate. Geraghty Z et al., 2021 Jan 8, J Cell Sci
    Read more
  • Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56. Hayward D et al., 2019 Oct 7, J Cell Biol
    Read more
  • MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling. Alfonso-Perez T et al., 2019 Apr 1, J Cell Biol
    Read more
  • CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization. Hayward D et al., 2019 Apr 1, J Cell Biol
    Read more

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