MAD1 antibody
GTX105079
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetMAD1L1
Overview
- SupplierGeneTex
- Product NameMAD1 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8379
- Target nameMAD1L1
- Target descriptionmitotic arrest deficient 1 like 1
- Target synonymsMAD1; MAD1 mitotic arrest deficient like 1; MAD1-like protein 1; mitotic arrest deficient 1-like protein 1; mitotic checkpoint MAD1 protein homolog; mitotic spindle assembly checkpoint protein MAD1; mitotic-arrest deficient 1, yeast, homolog-like 1; PIG9; tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y6D9
- Protein NameMitotic spindle assembly checkpoint protein MAD1
- Scientific DescriptionMAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size.Read more
- Septin 9 controls CCNB1 stabilization via APC/C(CDC20) during meiotic metaphase I/anaphase I transition in mouse oocytes.Read more
- Bub1 and CENP-U redundantly recruit Plk1 to stabilize kinetochore-microtubule attachments and ensure accurate chromosome segregation. Chen Q et al., 2021 Sep 21, Cell RepRead more
- The association of Plk1 with the astrin-kinastrin complex promotes formation and maintenance of a metaphase plate. Geraghty Z et al., 2021 Jan 8, J Cell SciRead more
- Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56. Hayward D et al., 2019 Oct 7, J Cell BiolRead more
- MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling. Alfonso-Perez T et al., 2019 Apr 1, J Cell BiolRead more
- CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization. Hayward D et al., 2019 Apr 1, J Cell BiolRead more