MADD antibody

GeneTex

MADD antibody

9

WB: 1:250-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Polyclonal

Unconjugated

MADD

MAP kinase activating death domain

DEEAH; DENN; differentially expressed in normal and neoplastic cells; IG20; insulinoma glucagonoma clone 20; MAP kinase-activating death domain protein; NEDDISH; Rab3 GDP/GTP exchange factor; rab3 GDP/GTP exchange protein; RAB3GEP; RabGEF

Rabbit

IgG

MAP kinase-activating death domain protein

Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

-20°C or -80°C,2°C to 8°C

12352203