MAPK8IP1 Antibody

Cusabio

MAPK8IP1 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

C-Jun-amino-terminal kinase-interacting protein 1; IB1; IB-1; islet-brain 1; JIP1; JIP-1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; PRKM8 interacting protein; PRKM8IP

Rabbit

IgG

C-Jun-amino-terminal kinase-interacting protein 1

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Human

-20°C or -80°C

12352203