IHC-P analysis of human heart tissue using GTX82965 MBD2 antibody at 1:100. Left to right:DAPI, MBD2, Merge. Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer.
IHC-P analysis of human heart tissue using GTX82965 MBD2 antibody at 1:100. Left to right:DAPI, MBD2, Merge. Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer.
MBD2 antibody, Internal
GTX82965
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetMBD2
Overview
- SupplierGeneTex
- Product NameMBD2 antibody, Internal - KO/KD Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 0.2-2.5 ug/ml. IHC-P: 2-10 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5-1 mg/ml
- ConjugateUnconjugated
- Gene ID8932
- Target nameMBD2
- Target descriptionmethyl-CpG binding domain protein 2
- Target synonymsdemethylase; DMTase; methyl-CpG-binding domain protein 2; NY-CO-41
- HostRabbit
- IsotypeIgG
- Protein IDQ9UBB5
- Protein NameMethyl-CpG-binding domain protein 2
- Scientific DescriptionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Methyl-CpG Binding Domain Protein 2 Inhibits the Malignant Characteristic of Lung Adenocarcinoma through the Epigenetic Modulation of 10 to 11 Translocation 1 and miR-200s. Pei YF et al., 2019 May, Am J PatholRead more