MBD2 antibody [N2C3]
GTX105622
Overview
- SupplierGeneTex
- Product NameMBD2 antibody [N2C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.48 mg/ml
- ConjugateUnconjugated
- Gene ID8932
- Target nameMBD2
- Target descriptionmethyl-CpG binding domain protein 2
- Target synonymsdemethylase; DMTase; methyl-CpG-binding domain protein 2; NY-CO-41
- HostRabbit
- IsotypeIgG
- Protein IDQ9UBB5
- Protein NameMethyl-CpG-binding domain protein 2
- Scientific DescriptionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells. Day RN et al., 2021, PLoS OneRead more
- The role of DNA methylation during anoxia tolerance in a freshwater turtle (Trachemys scripta elegans). Wijenayake S et al., 2016 Apr, J Comp Physiol BRead more