Western blot analysis of extracts of various cell lines using MBNL1 Polyclonal Antibody at dilution of 1:1000.
Western blot analysis of extracts of various cell lines using MBNL1 Polyclonal Antibody at dilution of 1:1000.
MBNL1 Polyclonal Antibody
E-AB-62123
Product group Antibodies
Overview
- SupplierElabscience
- Product NameMBNL1 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities.
- UNSPSC12352203