The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA066991(MCAM Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200)

MCAM Antibody

Name: MCAM Antibody
SKU: CSB-PA066991_C90
Availability: BackOrder

CSB-PA066991

ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry

Product group Antibodies

TargetMCAM

Overview

Supplier
Cusabio
Product Name
MCAM Antibody
Delivery Days Customer
20
Applications
Western Blot, ELISA, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID4162
Target name
MCAM
Target description
melanoma cell adhesion molecule
Target synonyms
CD146; cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; melanoma adhesion molecule; melanoma-associated antigen A32; melanoma-associated antigen MUC18; MelCAM; METCAM; MUC18; S-endo 1 endothelial-associated antigen
Host
Rabbit
Isotype
IgG
Protein IDP43121
Protein Name
Cell surface glycoprotein MUC18
Scientific Description
CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. In humans, the CD146 protein is encoded by the MCAM gene. Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Storage Instruction
-20°C or -80°C
UNSPSC
12352203

MCAM Antibody

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Overview

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