MCM3 antibody
GTX110241
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetMCM3
Overview
- SupplierGeneTex
- Product NameMCM3 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.71 mg/ml
- ConjugateUnconjugated
- Gene ID4172
- Target nameMCM3
- Target descriptionminichromosome maintenance complex component 3
- Target synonymsHCC5, P1-MCM3, P1.h, RLFB, DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, DNA replication factor MCM3, MCM3 minichromosome maintenance deficient 3, RLF subunit beta, cervical cancer proto-oncogene 5, hRlf beta subunit, minichromosome maintenance deficient 3, p102, replication licensing factor, beta subunit
- HostRabbit
- IsotypeIgG
- Protein IDP25205
- Protein NameDNA replication licensing factor MCM3
- Scientific DescriptionThe protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Gao Y, Duan Q, Wu N, et al. A heterogeneous cellular response to ionizing radiation revealed by single cell transcriptome sequencing. Am J Cancer Res. 2021,11(2):513-529.Read this paper
- Essawy MM, El-Sheikh SM, Raslan HS, et al. Function of gold nanoparticles in oral cancer beyond drug delivery: Implications in cell apoptosis. Oral Dis. 2021,27(2):251-265. doi: 10.1111/odi.13551Read this paper
- Sikorski K, Mehta A, Inngjerdingen M, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018,15(11):909-912. doi: 10.1038/s41592-018-0179-8Read this paper
- Guo L, Li X, Huang JX, et al. Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes. Cell Death Differ. 2012,19(12):1917-27. doi: 10.1038/cdd.2012.75Read this paper



