MEG (hemisulfate)

MedChem Express

MEG (hemisulfate) [3979-00-8]

10

3979-00-8

Research Use Only

C3H9N3S.1/2H2O4S

168.23

MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS) , with EC 50 s of 11.5, 110, and 60 microM for iNOS , ecNOS , and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock [1] [2] [3] [4] .

NC(NCCS)=N.O=S(O)(O)=O.[1/2]

12352200