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MI-3454

HY-136360
MedChem Express
CAS Number2134169-43-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.68
Molecular Weight636.73
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Overview

  • Supplier
    MedChem Express
  • Product Name
    MI-3454 [2134169-43-8]
  • Delivery Days Customer
    10
  • CAS Number
    2134169-43-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.68
  • Molecular Formula
    C32H35F3N8OS
  • Molecular Weight
    636.73
  • Scientific Description
    MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC 50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1 -rearranged or NPM1 -mutated leukemia through downregulation of key genes involved in leukemogenesis [1] .
  • SMILES
    O=CNC1(C2)CC2(CN3C(C#N)=CC4=C3C=CC(CN5CCC(NC6=C(C=C(CC(F)(F)F)S7)C7=NC(NC)=N6)CC5)=C4C)C1
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200