MICU2 Antibody, FITC conjugated

Cusabio

MICU2 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

MICU2

mitochondrial calcium uptake 2

1110008L20Rik, EFHA1, hMICU3, calcium uptake protein 2, mitochondrial, EF hand domain family A1, EF hand domain family, member A1, EF-hand domain-containing family member A1, Smhs2 homolog

Rabbit

IgG

Calcium uptake protein 2, mitochondrial

Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).

Human

-20°C or -80°C

41116161