MK-2206

MedChem Express

MK-2206 [1032349-77-1]

10

1032349-77-1

Research Use Only

99.39

C25H22ClN5O

443.93

MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC 50 s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. MK-2206 has anticancer activities [1] [2] .

O=C1NN=C2C3=C(N=C(C4=CC=C(C5(N)CCC5)C=C4)C(C6=CC=CC=C6)=C3)C=CN21.[H]Cl

2°C to 8°C

12352200