ML218

MedChem Express

ML218 [1346233-68-8]

10

1346233-68-8

Research Use Only

99.49

C19H26Cl2N2O

369.33

ML218 is a potent, selective and orally active T-type Ca 2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC 50 s of 310 nM and 270 nM for Cav3.2 and Cav3.3 , respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, K ATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier [1] .

O=C(NC[C@@H]1[C@@]2([H])CN(CCC(C)(C)C)C[C@@]12[H])C3=CC(Cl)=CC(Cl)=C3

-20°C,2°C to 8°C

12352200