ML218 [1346233-68-8]
T12076L
CAS Number1346233-68-8
Product group Chemicals
Estimated Purity99.45%
Molecular Weight369.33
Overview
- SupplierTargetMol Chemicals
- Product NameML218 [1346233-68-8]
- Delivery Days Customer14
- CAS Number1346233-68-8
- CertificationResearch Use Only
- Chemical NameML218
- Estimated Purity99.45%
- Molecular FormulaC19H26Cl2N2O
- Molecular Weight369.33
- Scientific DescriptionML218 is an orally active, selective, potent, and blood-brain barrier-crossing inhibitor of T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) (IC50 for Cav3.2 and Cav3.3 is 310 nM and 270 nM, respectively).ML218 inhibits the burst activity of neurons in the subthalamic nucleus (STN).
- Shelf life instruction3 years
- SMILES[H][C@@]12CN(CCC(C)(C)C)C[C@]1([H])[C@H]2CNC(=O)c1cc(Cl)cc(Cl)c1
- Storage Instruction-20°C
- UNSPSC12352200
References
- Xiang Z, Thompson AD, Brogan JT, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011,2(12):730-742.Read this paper
