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ML218 (hydrochloride)

HY-103309A
MedChem Express
CAS Number2319922-08-0
Product group Chemicals
Molecular Weight405.79
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Overview

  • Supplier
    MedChem Express
  • Product Name
    ML218 (hydrochloride) [2319922-08-0]
  • Delivery Days Customer
    10
  • CAS Number
    2319922-08-0
  • Certification
    Research Use Only
  • Molecular Formula
    C19H27Cl3N2O
  • Molecular Weight
    405.79
  • Scientific Description
    ML218 hydrochloride is a potent, selective and orally active T-type Ca 2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC 50 s of 310 nM and 270 nM for Cav3.2 and Cav3.3 , respectively. ML218 hydrochloride inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 hydrochloride has no significant inhibition of L- or N-type calcium channels, K ATP or hERG potassium channels. ML218 hydrochloride can penetrate the blood-brain barrier [1] .
  • SMILES
    O=C(NC[C@@H]1[C@@]2([H])CN(CCC(C)(C)C)C[C@@]12[H])C3=CC(Cl)=CC(Cl)=C3.[H]Cl
  • UNSPSC
    12352200