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ML218 hydrochloride [2319922-08-0]

ML218 hydrochloride [2319922-08-0]

T12076
TargetMol Chemicals
CAS Number2319922-08-0
Product group Chemicals
Molecular Weight405.79
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    ML218 hydrochloride [2319922-08-0]
  • Delivery Days Customer
    44
  • CAS Number
    2319922-08-0
  • Certification
    Research Use Only
  • Chemical Name
    ML218 hydrochloride
  • Molecular Formula
    C19H27Cl3N2O
  • Molecular Weight
    405.79
  • Scientific Description
    ML218 hydrochloride is a selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor (Cav3.2 and Cav3.3 with IC50s of 310 nM and 270 nM , respectively).
  • Shelf life instruction
    3 years
  • SMILES
    C(NC(=O)C1=CC(Cl)=CC(Cl)=C1)[C@H]2[C@]3([C@@]2(CN(CCC(C)(C)C)C3)[H])[H].Cl
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Xiang Z, Thompson AD, Brogan JT, et al. The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson's Disease. ACS Chem Neurosci. 2011,2(12):730-742.
    Read this paper

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