MOB1B antibody [1H2]

GeneTex

MOB1B antibody [1H2]

9

WB: 1:2000. IHC-P: 1:150. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1H2

1 mg/ml

Unconjugated

MOB1B

MOB kinase activator 1B

MATS2; MOB kinase activator 1B; mob1 homolog 1A; MOB1 Mps One Binder homolog B; MOB1, Mps One Binder kinase activator-like 1A; mob1A; MOB4A; MOBKL1A; mps one binder kinase activator-like 1A

Mouse

IgG2a

MOB kinase activator 1B

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Human

-20°C or -80°C,2°C to 8°C

12352203