Momelotinib [1056634-68-4]
T1849
CAS Number1056634-68-4
Product group Chemicals
Estimated Purity98.75%
Molecular Weight414.46
Overview
- SupplierTargetMol Chemicals
- Product NameMomelotinib [1056634-68-4]
- Delivery Days Customer4
- CAS Number1056634-68-4
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameMomelotinib
- Estimated Purity98.75%
- Molecular FormulaC23H22N6O2
- Molecular Weight414.46
- Scientific DescriptionMomelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
- Shelf life instruction3 years
- SMILESO=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
- Storage Instruction-20°C
- UNSPSC12352200
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