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Larotrectinib (LOXO-101)

M6151
AbMole BioScience
CAS Number1223403-58-4
Product group Chemicals
Molecular Weight428.44
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Monastrol [1223403-58-4]
  • Delivery Days Customer
    9
  • CAS Number
    1223403-58-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Molecular Formula
    C21H22F2N6O2
  • Molecular Weight
    428.44
  • Scientific Description
    Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
  • SMILES
    OC1CCN(C1)C(=O)NC2=C3N=C(C=C[N]3N=C2)N4CCCC4C5=CC(=CC=C5F)F
  • UNSPSC
    12352200