Motesanib

MedChem Express

Motesanib [453562-69-1]

10

453562-69-1

Research Use Only

99.96

C22H23N5O

373.45

Motesanib (AMG 706) is a potent ATP-competitive inhibitor of? VEGFR1/2/3 ?with? IC 50 s?of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret.

O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3

-20°C,2°C to 8°C

12352200