MRTX-1257 [2206736-04-9]

TargetMol Chemicals

MRTX-1257 [2206736-04-9]

9

2206736-04-9

Chemical

Research Use Only

MRTX-1257

99.07%

C33H39N7O2

565.71

MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment.

3 years

CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12

-20°C

12352200