MS1943

MedChem Express

MS1943 [2225938-17-8]

10

2225938-17-8

Research Use Only

98.92

C42H54N8O3

718.93

MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency ( IC 50 =120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2 . (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578)) [1] .

CC(C)N(N=C1)C2=C1C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C4=CC=C(N=C4)N(CC5)CCN5CCNC(CC67C[C@H]8C[C@H](C[C@H](C8)C7)C6)=O)=C2

-20°C,2°C to 8°C

12352200