MTI-31

MedChem Express

MTI-31 [1567915-38-1]

10

1567915-38-1

Research Use Only

99.98

C26H30N6O3

474.55

MTI-31 (LXI-15029) is a potent, orally active and highly selective inhibitor of mTORC1 and mTORC2. MTI-31 is selective for mTOR (Kd: 0.20 nM) versus PIK3CA, PIK3CB and PIK3G with >5,000 fold selectivity in mTOR binding assays. MTI-31 shows an IC50 of 39 nM for mTOR in LANCE assay of mTOR substrate phosphorylation with 100 microM ATP. MTI-31 can be used for the research of breast cancer[1].

C[C@@H]1N(CCOC1)C2=NC3=C(C=CC(C4=CC(C(NC)=O)=CC=C4)=N3)C(N5C6CCC5COC6)=N2

-20°C,2°C to 8°C

12352200