ProductsBack/mTOR (phospho Ser2448) antibody

mTOR (phospho Ser2448) antibody detects mTOR (phospho Ser2448) protein at cytoplasm by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: mTOR (phospho Ser2448) stained by mTOR (phospho Ser2448) antibody (GTX132803) diluted at 1:500. Blue: Fluoroshield with DAPI (GTX30920).

mTOR (phospho Ser2448) antibody

GTX132803

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetMTOR

Overview

Supplier
GeneTex
Product Name
mTOR (phospho Ser2448) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1.5 mg/ml
Conjugate
Unconjugated
Gene ID2475
Target name
MTOR
Target description
mechanistic target of rapamycin kinase
Target synonyms
FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS, serine/threonine-protein kinase mTOR, FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP-rapamycin associated protein, FKBP12-rapamycin complex-associated protein 1, mammalian target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, rapamycin target protein 1, tyrosine-protein kinase mTOR
Host
Rabbit
Isotype
IgG
Protein IDP42345
Protein Name
Serine/threonine-protein kinase mTOR
Scientific Description
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Zhong Y, Jin R, Luo R, et al. Diosgenin Targets CaMKK2 to Alleviate Type II Diabetic Nephropathy through Improving Autophagy, Mitophagy and Mitochondrial Dynamics. Nutrients. 2023,15(16). doi: 10.3390/nu15163554
Read this paper
Tian X, Wei Y, Hou R, et al. Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization. Chin Med. 2023,18(1):79. doi: 10.1186/s13020-023-00787-9
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Parija M, Adhya AK, Mishra SK. G-protein-coupled receptor 141 mediates breast cancer proliferation and metastasis by regulating oncogenic mediators and the p-mTOR/p53 axis. Oncotarget. 2023,14:466-480. doi: 10.18632/oncotarget.28433
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Hashikawa-Hobara N, Otsuka A, Okujima C, et al. CGRP overexpression does not alter depression-like behavior in mice. PeerJ. 2021,9:e11720. doi: 10.7717/peerj.11720
Read this paper
Mori Y, Takeuchi A, Miyagawa K, et al. CD133 prevents colon cancer cell death induced by serum deprivation through activation of Akt-mediated protein synthesis and inhibition of apoptosis. FEBS Open Bio. 2021,11(5):1382-1394. doi: 10.1002/2211-5463.13145
Read this paper
Liu Z, Ma T, Duan J, et al. MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways. Mol Med Rep. 2021,23(2):pii: 154. doi: 10.3892/mmr.2020.11793.
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Cheung CHY, Hsu CL, Lin TY, et al. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. J Biomed Sci. 2020,27(1):75. doi: 10.1186/s12929-020-00668-5
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Li J, Ma J, Tian Y, et al. Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling. J Ethnopharmacol. 2020,257:112796. doi: 10.1016/j.jep.2020.112796
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Li H, Xue X, Li L, et al. Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway. Neurotox Res. 2020,37(4):996-1008. doi: 10.1007/s12640-020-00165-5
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Peng Q, Chen B, Wang H, et al. Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes. Aging (Albany NY). 2019,11(23):11520-11540. doi: 10.18632/aging.102552
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mTOR (phospho Ser2448) antibody

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