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ProductsBack/MUC2 antibody [C3], C-term

MUC2 antibody [C3], C-term

Research Use Only
GTX100664
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat
TargetMUC2
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Overview

  • Supplier
    GeneTex
  • Product Name
    MUC2 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.32 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4583
  • Target name
    MUC2
  • Target description
    mucin 2, oligomeric mucus/gel-forming
  • Target synonyms
    MLP; MUC-2; mucin 2, intestinal/tracheal; mucin-2; SMUC
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ02817
  • Protein Name
    Mucin-2
  • Scientific Description
    This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
  • Reactivity
    Human, Mouse, Porcine, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases. Ilani T et al., 2023 Jan 16, EMBO J
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  • Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer. Sharpen JDA et al., 2022 Jan 11, Nat Commun
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  • An Active Fraction of Trillium tschonoskii Promotes the Regeneration of Intestinal Epithelial Cells After Irradiation. Song F et al., 2021, Front Cell Dev Biol
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  • Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis. Nishio J et al., 2021 Oct 12, Sci Rep
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  • Role for Mucin-5AC in Upper and Lower Airway Pathogenesis in Mice. Cho HY et al., 2021 Jul, Toxicol Pathol
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  • RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Gudino V et al., 2021 Apr 20, Nat Commun
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  • IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Layunta E et al., 2021 Feb 16, Cell Rep
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  • Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis. Miyazaki T et al., 2021 Jan 12, Sci Rep
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  • Effects of different doses lipopolysaccharides on the mucosal barrier in mouse intestine. Li C et al., 2020 Dec, Res Vet Sci
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  • Me6TREN targets beta-catenin signaling to stimulate intestinal stem cell regeneration after radiation. Wang S et al., 2020, Theranostics
    Read more