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ProductsBack/MUC2 antibody [C3], C-term

MUC2 antibody [C3], C-term

GTX100664
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Porcine, Rat
TargetMUC2
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Overview

  • Supplier
    GeneTex
  • Product Name
    MUC2 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.9 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID4583
  • Target name
    MUC2
  • Target description
    mucin 2, oligomeric mucus/gel-forming
  • Target synonyms
    MLP; MUC-2; mucin 2, intestinal/tracheal; mucin-2; SMUC
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ02817
  • Protein Name
    Mucin-2
  • Scientific Description
    This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
  • Reactivity
    Human, Mouse, Porcine, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis.
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  • Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism.
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  • Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2-activated gammadeltaT17 cell and macrophage polarization.
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  • Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection.
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  • PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice.
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  • Tannins amount determines whether tannase-containing bacteria are probiotic or pathogenic in IBD.
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  • FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
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  • Acute infection with Brachyspira hyodysenteriae affects mucin expression, glycosylation, and fecal MUC5AC.
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  • Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification.
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  • Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice.
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